Search results for "IGRA test"

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Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease

2015

Cytotoxic molecules such as granulysin, perforin and granzymes produced by cytolytic T cells directly contribute to immune defense against tuberculosis (TB). In search for novel TB biomarkers, we have evaluated the levels of granzyme A in plasma obtained from QuantiFERON-TB Gold In tube (QFT-IT) assays from patients with active TB disease and subjects with latent TB infection (LTBI).Granzyme A serum levels in TB patients were significantly lower than values found in LTBI subjects even after subtraction of the unstimulated levels from the antigen-stimulated responses. The receiver operator characteristics (ROC) curve analysis comparing TB patients and LTBI groups, showed that at a cut-off va…

AdultMaleTuberculosisTuberculosiImmunologyDisease; Granzyme A; IFN-γ; IGRA tests; Infection; Tuberculosis; Adult; Antigens Bacterial; Biomarkers; Case-Control Studies; Female; Granzymes; Humans; Interferon-gamma; Latent Tuberculosis; Male; Middle Aged; Mycobacterium tuberculosis; ROC Curve; Tuberculosis; Young Adult; Immunology and Allergy; ImmunologyMycobacterium tuberculosiIFN-γGranzymesMycobacterium tuberculosisIGRA testInterferon-gammaYoung AdultLatent TuberculosismedicineHumansTuberculosisImmunology and AllergyDiseaseGranulysinGranzymeAntigens BacterialLatent TuberculosibiologyLatent tuberculosisGranzyme AMycobacterium tuberculosisBiomarkerMiddle Agedbacterial infections and mycosesmedicine.diseasebiology.organism_classificationROC CurvePerforinGranzymeCase-Control StudiesImmunologybiology.proteinGranzyme ABiomarker (medicine)FemaleInfectionCase-Control StudieBiomarkersHuman
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New tools for detecting latent tuberculosis infection: evaluation of RD1-specific long-term response

2009

Abstract Background Interferon-gamma (IFN-γ) release assays (IGRAs) were designed to detect latent tuberculosis infection (LTBI). However, discrepancies were found between the tuberculin skin test (TST) and IGRAs results that cannot be attributed to prior Bacille Calmètte Guerin vaccinations. The aim of this study was to evaluate tools for improving LTBI diagnosis by analyzing the IFN-γ response to RD1 proteins in prolonged (long-term response) whole blood tests in those subjects resulting negative to assays such as QuantiFERON-TB Gold In tube (QFT-IT). Methods The study population included 106 healthy TST+ individuals with suspected LTBI (recent contact of smear-positive TB and homeless) c…

AdultMalemedicine.medical_specialtyTuberculosisTuberculinlcsh:Infectious and parasitic diseasesMycobacterium tuberculosisInterferon-gammaYoung AdultMedical microbiologyAntigenLatent TuberculosismedicineHumanslcsh:RC109-216tuberculosis latent infection IGRA testAntigens BacterialLatent tuberculosisbiologyTuberculin Testbusiness.industryMycobacterium tuberculosisMiddle Agedmedicine.diseasebiology.organism_classificationbacterial infections and mycosesVaccinationLong term responseInfectious DiseasesImmunologyFemaleReagent Kits DiagnosticbusinessResearch ArticleBMC Infectious Diseases
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